Endocrine Abstracts

Introduction: Growth hormone (GH) treatment in congenital growth hormone deficiency (CGHD) is indicated to improve the prognosis of the statural prognosis. The aim of this study is to identify the predictive factors of a favorable response to GH therapy.Patients & Methods: This is a retrospective study, conducted over a period of 27 years, including 30 patients with CGHD treated with hormonal therapy.Results: The CGHD was diagn...

Introduction: Mixed connective tissue disease (MCTD), also known as Sharp´s syndrome is a rare autoimmune disease (AD), characterized by the presence of high titers of a distinctive autoantibody: ribonucleoprotein auto-antibody (anti-RNP). It presents with varied overlapping symptoms of different connective tissue disorders which may appear sequentially over time. As other AD, MCTD may be associated with one or more AD, such as autoimmune thyroid disorders (AITD).<p c...

Introduction: Type 1 diabetes mellitus (T1DM) is the result of the autoimmune destruction of beta-cells of the endocrine pancreas, leading to absolute insulin deficiency. The process of this autoimmune destruction occurs in genetically susceptible individuals with positive relevant autoantibodies. T1DM may be associated with other autoimmune diseases (AD) such as autoimmune thyroid disorders (AITD). Patients and methods: It is a descriptive retrospective...

Introduction: Autoimmune hepatitis (AIH) is a generally progressive and chronic liver disease that can occur both in children and adults. Although the cause of AIH is unknown, aberrant auto-reactivity is thought to have a role in its pathogenesis. The diagnosis is based on clinical presentation, biological and histological findings. Like other autoimmune diseases (AD), AIH can be associated with one or more AD either organ-specific or non-organ specific AD. <p class="abste...

Introduction: Graves’ disease (GD) is the most common cause of hyperthyroidism in pediatric patients, up to 95% in some studies.Observation: We report the observation of a 6-year-old female who consulted for a behavioral disorder made of agitation and lack of concentration. She had a family history of autoimmune thyroid disease. On examination, an accelerated statural growth rate of +2DS was noted. She had a significant palpebral retraction without ...

Introduction: Cardiothyreosis is the consequence of the effects of excess free thyroid hormones on the vascular wall and myocardium. This complication is the most serious aspect of hyperthyroidism. Rhythm disorders and heart failure are the most frequently noted. The prevalence of coronary insufficiency is lower. The aim of this study is to evaluate the characteristics of coronary insufficiency in patients with hyperthyroidism.Method: This is a retrospec...

Amiodarone is considered by many the most potent antiarrhythmic drug. The other side of the coin is that it’s associated with many side effects including disturbances in the thyroid function, which can be seen in 14 to 18 % of the cases (1). This case is about a 56-year-old male patient with a history of mitral valve disease who was on Amiodarone for 3 years. His personal history was notable with Epilepsy of unknow etiology for which he was on sodium valproate. During fol...

Introduction: Exogenous insulin autoimmune syndrome (EIAS) is a rare cause of hypoglycemia in patients with diabetes treated with exogenous insulin. Flares of auto-immune diseases following covid-19 infection have been widely reported.Case report: A 15-year-old type 1 diabetes female patient treated with detemir and glulisine was diagnosed with EIAS based on major glycemic instability and an elevated anti exogenous insulin autoantibody titer of 40 IU (NV...

Pituitary apoplexy is a rare condition and gestational pituitary apoplexy (GPA) is even more exceptional. Clinical presentation of GPA is often non-specific overlapping with other conditions, making its diagnosis challenging. Additionally, therapeutic management is often limited since it depends on both the mother’s and the fetus’s prognosis. Herein we report of a woman who was diagnosed with GPA and we discuss the management of her case. A 34-year-old woman with no ...

Background and aim: Congenital Growth hormone deficiency (CGHD) may result from genetic or congenital disorders of pituitary development. It could be isolated or combined with other types of hypopituitarism. This study aims to evaluate the prevalence of combined hypopituitarism and its associated factors in patients with CGHD.Patients and Methods: We conducted a retrospective study (1991-2019) at the Endocrinology department of Hedi Chaker University Hos...